FISCHER LABORATORY OF GENOME REGULATION
Selected work in genome regulation and tumour suppression

Publications

Selected work in genome regulation and tumour suppression

A selected record spanning p53, RFX7, cell-cycle transcription, promoter architecture and integrative genomics.
2026

Nature Genetics

Transcriptional interference revisited

2025

Nucleic Acids Research

p53 reveals principles of chromatin remodeling and enhancer activation

2025

Nature Genetics

Gene regulation by convergent promoters

2024

Cell Death Discovery

p53 target ANKRA2 cooperates with RFX7 to regulate tumor suppressor genes

2024

Cell Death & Differentiation

Determinants of p53 DNA binding, gene regulation, and cell fate decisions

2024

BBA Reviews on Cancer

Gene regulation by tumor suppressor p53—the omics era

2023

Cell Death Discovery

Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

2023

Molecular Oncology

The landscape of human p53-regulated long non-coding RNAs reveals critical host gene co-regulation

2022

Trends in Biochemical Sciences

Coordinating gene expression during the cell cycle

2022

NAR Cancer

TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, RFX7 and cell-cycle gene regulation

2022

Oncogene

p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance

2021

Nucleic Acids Research

Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress